Weight Loss and Vascular Function

Weight loss and vascular function: the good and the unknown.

Obesity has emerged recently as a major epidemic and is turning out to be a key driving force for the rapid escalation not just in the rates of type 2 diabetes mellitus, but of cardiovascular disease as well. It is estimated that currently 300 000 deaths per year are attributable to obesity1 in the United States, with a significant proportion being attributable to cardiovascular events.2 It is ...

Weight loss and endothelial function in obesity.

Endothelial dysfunction, a pathologic feature of obesity, predicts the occurrence of cardiovascular disease (1,2), and is felt to mediate the increased cardiovascular risk associated with a number of classical and nonclassical risk factors. However, the pathogenesis of endothelial dysfunction in obesity remains uncertain. In this field, the major questions center on the relative roles of insuli...

Gene expression profiling during intensive cardiovascular lifestyle modification: Relationships with vascular function and weight loss

Heart disease and related sequelae are a leading cause of death and healthcare expenditure throughout the world. Although many patients opt for surgical interventions, lifestyle modification programs focusing on nutrition and exercise have shown substantial health benefits and are becoming increasing popular. We conducted a year-long lifestyle modification program to mediate cardiovascular risk...

Adiposity and vascular aging: indication for weight loss?

Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function

Both the history of obesity and weight loss may change how menopause affects metabolic health. The purpose was to determine whether obesity and/or weight loss status alters energy balance (EB) and subsequent weight gain after the loss of ovarian function. Female lean and obese Wistar rats were randomized to 15% weight loss (WL) or ad libitum fed controls (CON). After the weight loss period, WL ...